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By expanding proteome complexity, PTMs not only govern general signal transduction but also precisely regulate TLR signaling through reversible modifications, ranging from conventional phosphorylation, ubiquitylation, methylation, and acetylation to the more recently discovered or unconventional modification, which include, but are not limited to, (de)SUMOylation, desuccinylation, S-nitrosylation, and O-GlcNAcylation

Wrap the ice in cloth to protect the skin and never exceed 15 minutes in one application

Researchers must ensure their protocols comply with institutional guidelines and regulations for research compound use

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